Physician-Led Medical Spa
Portland, ORInjectables, lasers, facials and regenerative care from a doctor-led team in NE Portland, with a free consultation to start.
Your Neighborhood Medical Spa in NE Portland
Ortho-Rejuv Wellness and Aesthetics is a physician-led medical spa in the Providence Plaza building on NE Hoyt Street, across from Providence Portland Medical Center. Dr. Natalie Mesnier, MD, founded the practice to bring medical training to aesthetic care, so every plan starts with your skin, your health history and your goals, not a menu of add-ons. Portland patients come to us from the Hollywood District, Laurelhurst, Irvington, the Pearl and downtown for natural results that still look like them.

Treatments at Our Portland Med Spa
- InjectablesWrinkle relaxers, fillers, lip filler, biostimulators
- Laser TreatmentsAerolase, resurfacing, hair and spider vein removal
- Facials & PeelsLuxe Facial, DiamondGlow, microneedling, peels
- Face & Body RejuvenationNeoGen plasma, T-Shape contouring, anti-aging
- Regenerative AestheticsPRP, PRF, peptides and exosomes for skin and hair
- Wellness & LongevityWeight loss, wellness shots, lymphatic massage
Real Results From Our Portland Patients
“After three weeks I saw major changes. My melasma is much lighter.” Emiko Kogure, patient of Dr. Mesnier · Google review
Getting to Our Portland Clinic
We are inside Providence Plaza on NE Hoyt Street, minutes from I-84 and the Hollywood Transit Center.
- Providence PlazaSuite 626, across from Providence Hospital
- Easy AccessMinutes from I-84 and NE Sandy Blvd
- Free ConsultTalk through your goals at no cost
- FinancingMonthly plans through Cherry
How Your First Visit Works
- Book your free consultationChoose a time online or call the front desk.
- Meet your providerWe look at your skin, history and goals, and answer every question.
- Get a clear planYou leave with recommended treatments, timing and pricing.
- Start when you are readyMany treatments can begin the same day.
Meet Your Portland Care Team
Physicians and Certified Advanced Estheticians who work together on every plan.




Portland Med Spa FAQs
Where is your Portland medical spa?
We are at 5050 NE Hoyt St, Suite 626, in the Providence Plaza building across from Providence Portland Medical Center in NE Portland, OR 97213.
Why do Portland patients choose Ortho-Rejuv?
Physician-led care, with a doctor on every treatment plan. Free consultations, with honest advice about what will and won’t help. Aerolase, fractional laser and NeoGen plasma technology in one clinic. Ageless AI preview so you can see a likely result before you commit. Cherry financing with monthly payment plans. Easy to reach from I-84 and the NE Sandy Blvd corridor.
Is a doctor involved in my treatment?
Yes. Ortho-Rejuv is physician-led. Dr. Natalie Mesnier, MD, and Dr. Nancy Yen Shipley, MD, oversee treatment plans, and injectables are placed by our medical team.
Do you offer free consultations?
Yes. Your first consultation is free. We review your goals and skin and give you a clear plan with pricing before you decide anything.
Can I pay for treatments over time?
Yes. We offer Cherry financing, which lets many patients split treatments into monthly payments.
Which treatments are most popular with Portland patients?
Wrinkle relaxers, dermal fillers, Aerolase laser treatments, DiamondGlow and Luxe facials, microneedling and PRP are among the most requested services at our Portland clinic.



