Doctor-led aesthetic and regenerative care about 30 minutes up I-205, with a free consultation to start.
Patients from Stafford, West Linn, Lake Oswego and Wilsonville travel to Ortho-Rejuv for care they trust to a physician. Our medical spa is in NE Portland, about a 30-minute drive up I-205, and it is led by Dr. Natalie Mesnier, MD. We focus on natural, lasting results: lasers that treat the cause of sun damage and redness, injectables placed with a light hand, and regenerative treatments that help your skin repair itself.

“She checked on me daily while I was recovering, and I knew I was in good hands.” Robyn Washburn, NeoGen Plasma Resurfacing patient · Google review
Take I-205 north to I-84 west and exit toward NE Sandy Blvd. We are inside Providence Plaza on NE Hoyt Street in Portland.
Physicians and Certified Advanced Estheticians who work on every plan together.




Our clinic is in NE Portland at 5050 NE Hoyt St, Suite 626. Patients from Stafford, West Linn and Lake Oswego usually reach us in about 30 minutes by I-205.
Physician-led care, from consultation to follow-up. About 30 minutes from Stafford via I-205. Aerolase Age-Reverse and Neo lasers for sun damage, redness and acne. NeoGen plasma for lifting and tightening. Free consultations and an Ageless AI preview of your result. Cherry financing with monthly payment plans.
Aerolase lasers treat redness, sun damage, uneven tone, acne and fine lines with little to no downtime. Your provider will tell you if it is a good fit at your free consultation.
NeoGen treatments range from light to deep. Lighter passes have little downtime, while deeper resurfacing needs several days of healing, and we check on you during recovery.
Injectables are placed by our medical team under physician oversight, led by Dr. Natalie Mesnier, MD.
Use the Book Appointment button on this page or call (503) 446-6360. Your first consultation is free.

Venus is a Certified Advanced Esthetician, Certified Phlebotomy Technician, and pre-nursing student with a passion for medical aesthetics and patient-centered care. She is dedicated to helping clients achieve healthy, radiant skin through result-driven, customized treatments tailored to their unique needs. As a patient advocate at heart, Venus loves working with all skin types and creating long-term skincare plans that focus on both visible results and overall skin health.
Her favorite treatments include Aerolase, NeoGen, and microneedling, innovative treatment options that deliver real, transformative outcomes. Outside of the treatment room, Venus enjoys creating social media content, exploring new food spots, and spending time with friends and family

Certified Advanced Esthetician




Dr. Natalie Mesnier, the driving force behind Ortho-Rejuv Wellness and Aesthetics, stands at the forefront of aesthetic innovation. With a rich background in the aesthetic realm, she is notably skilled in anti-aging laser therapies, skin revitalization, and the meticulous use of injectables and fillers. Alongside her certifications in advanced aesthetic procedures, including PRP and neuromodulator applications, Dr. Mesnier’s mission is singular: to empower patients to experience and radiate their utmost beauty and confidence.